Functions of intragenic transcription

A diagram of one possible mechanism of function for intragenic gene expression, in which intragenic gene expression leads to the production of an N-terminally truncated protein that is missing a domain normally found in the full-length protein.

As a graduate student/postdoc in the Fred Winston lab, I did data science work on a project studying potential functions for intragenic transcription in wild-type S. cerevisiae.

In this project, we applied high-resolution assays of transcription initiation to discover instances of intragenic transcription that are regulated by cellular stresses, in order to study the roles that this transcription might play in the stress response.

Preliminary results from this work appear in chapter 4 of my PhD dissertation.